DEVELOPMENT AND EVALUATION OF NOVEL NANOPARTICLE-BASED DRUG DELIVERY SYSTEMS FOR TARGETED BIOMEDICAL APPLICATION

Abstract

Nanoparticle drug delivery systems have been developed over the past few years and present new ways to improve the therapeutic efficacy, safety, and specificity of drugs within the scope of biological technologies. Our research aimed to develop a new type of nanoparticle for targeted drug delivery for patients suffering from chronic illnesses. The nanoparticles developed used biocompatible and biodegradable materials to create nanoparticles with enhanced drug encapsulation and stability and controlled release properties. The physicochemical properties of the nanoparticles developed were evaluated through multiple parameters, including size, surface area, zeta potential, and drug loading efficiency. In addition, the in vitro drug release profile of the nanoparticles was examined in relation to cellular uptake, biocompatibility and therapeutic efficacy using cell culture models. The results of these studies showed that the nanoparticles developed had a uniform shape and size, contained drug at a significantly higher level than did traditional pharmaceutical preparations, and released drug over time at a rate to maintain therapeutic efficacy. Moreover, the nanoparticles developed had an improved cellular uptake relative to conventional pharmaceutical drug formulations and enhanced therapeutic activity vs. traditional pharmaceutical formulations. The overall conclusion from the research is that nanoparticles have the potential to unambiguously provide targeted therapeutic agents and provide improved safety and specific delivery of therapeutic agents, in comparison to traditional dosing methods.

Keywords: Nanoparticle-based drug delivery, Targeted drug delivery, Biomedical applications, Controlled drug release, Drug encapsulation, Biocompatibility, Cellular uptake, Surface functionalization, Therapeutic efficacy, Nanomedici