DEVELOPMENT AND CHARACTERIZATION OF CEFIXIME IN SITU GEL FOR BACTERIAL MENINGITIS

Abstract

Among all the routes, parenteral route of drug administration exhibits rapid effect, efficient drug delivery, avoidance of gastric irritation, prevention of first pass metabolism and easy administration to unconscious patients. In most of the cases frequent administration is unsuitable as it causes more risk of infection. Development of in situ biodegradable injectables solve this problem as it consists of polymers and it is administered in liquid form and converted into gel on coming across a stimulus. The aim of this research work was to develop in situ gelling system of cefixime based on biodegradable polymers. Cefixime is used in urinary tract infection as 20% of drug excreted by kidney in active form so preferred in UTIs. Therapy is for 7 days and conventional parenteral solution of cefixime need frequent administration that is painful and expensive. Hence, parenteral in-situ gel of cefixime was designed. The developed formulation contains temperature dependent polymer poloxamer P407 and pH dependent polymer Carbopol 934 which showed solution to gel transition from room temperature to body temperature and pH from 6.0 to physiological pH of body respectively. The formulation was evaluated for physical parameters: found clear in appearance, pH was within the tolerable range of body and show remarkable gelling capacity. Formulation also exhibited pseudo plastic behaviour on rheological studies. FTIR and DSC studies were performed for purity and compatibility studies of formulation. In vitro release studies showed that the formulation with required concentration of polymers prolonged the release for eleven days and followed first order kinetics. The prepared formulation was effective, stable and prolonged release for eleven days.

Keywords: In situ biodegradable injection, gastric irritation, first pass metabolism, pseudo plastic behaviour.

https://doi.org/10.5281/zenodo.17035381