ASSESSMENT OF PLATELET COUNT AND ITS ASSOCIATION WITH STROKE SEVERITY IN PATIENTS WITH ACUTE ISCHEMIC STROKE FROM LARKANA

Abstract

Background: Platelets are crucial in vascular disease progression, with mean platelet volume (MPV) being a significant physiological variable. Large platelets are more reactive, produce prothrombotic factors, and aggregate easily. Their characteristics are determined by their bone marrow megakaryocyte. Platelet production mechanisms are unclear, but they may be controlled by hormonal factors. Methodology: This cross-sectional study was conducted in private clinics and neurology wards in the Larkana region between June to October 2024. The sample size consisted of 120 cases and 120 controls, A clinical diagnosis of stroke was made, and brain imaging confirmed the diagnosis. The NIHS scale, used to evaluate stroke patients, was used to track progress and predict prognosis. Blood samples were collected and analyzed using an automated hematology analysis system. The results were compared using the t-test for independent samples and an independent sample t-test for differences in mean values among cases with varying illness severity scores. Results: A study found that 68.3% of stroke cases were male, with 31.7% female. The majority were from metropolitan areas, with an average age of 52.42 years. The majority of patients were aged 27-30, with 7% experiencing a small stroke, 26% a moderate stroke, 37% a moderate to severe stroke, and 30% a severe stroke. The study found no significant difference in mean platelet count between 25-35 age groups. Conclusion: The study concludes that ischemic stroke is more common in males and middle-aged and older adults, with more cases in urban areas, and that stroke contributes to decreased platelet count.